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The "tired Joe" (Terence Hill) is a cunning and streetwise poker player. Not a con artist, but a cold strategist who must defend his luck time and again with his fists and a gun. The "Little One" (Bud Spencer), a mountain of a man, is an insurance agent on the hunt for train robbers. By chance, the two old friends meet again and discover that they are both looking for the same man: Bill St. Antonio.